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Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus.

Fuliang HU, Hepburn HR, Xuan H, Chen M, Daya S, Radloff SE

College of Animal Science, Zhejiang University, Hangzhou 310029, China.

The effects of ethanol (EEP) and water (WSD) extracts of propolis collected from north China on blood glucose, blood lipid and free radicals in rats with diabetes mellitus were studied. The results show that EEP and WSD led to decreased levels of blood glucose (FBG), fructosamine (FRU), malonaldehyde (MDA), nitric oxide (NO), nitric oxide synthetase (NOS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) in serum of fasting rats; and to increased serum levels of high-density lipoprotein cholesterol (HDL-C) and superoxide dismutase (SOD). This suggests that propolis can control blood glucose and modulate the metabolism of glucose and blood lipid, leading to decreased outputs of lipid peroxidation and scavenge the free radicals in rats with diabetes mellitus.

Published 4 January 2005 in Pharmacol Res, 51(2): 147-52.
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