Diabetes Research Today is a free monthly online journal that collates and summarizes the latest research about Diabetes, including details on insulin, type i, type ii, diet, treatment, prevention. | ||||||||
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ABCA1, ApoA-I and type II DM.Saleheen D Department of Biological and Biomedical Sciences, Aga Khan University, Stadium road, Karachi, Pakistan. danishsaleheen@yahoo.com The ATP-binding cassette transporter 1 (ABCA1) is a trans-membrane peptide that is involved in the lipidification of ApoA-I. ABCA1 gene was initially implicated in Tangier disease and familial hypoalphalipoproteinemia and has been shown to be associated with coronary artery disease and atherosclerosis as well. Recently, a haplotype in ABCA1 gene was associated with increased risk of type II diabetes mellitus (DM). In this report, a relationship between ApoA-I, DM and ABCA1 has been emphasized. Published 1 August 2005 in Biochem Biophys Res Commun, 334(4): 971-2.
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