Diabetes Research Today is a free monthly online journal that collates and summarizes the latest research about Diabetes, including details on insulin, type i, type ii, diet, treatment, prevention.

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

Finck BN, Kelly DP

Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.

Published 2 March 2006 in J Clin Invest, 116(3): 615-22.
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